Individual study plan

Bedside assessment of microvascular dysfunction

method evaluation in clinical studies

Disposition

  • Introduction and Background: Introduction to the topic, research objectives

  • Research plan and Methodology: Study designs, methods and analysis

  • Timeline and Milestones: Project timeline with key milestones

  • Resources and Support: Overview of resoruces and support

  • Discussion and Feedback: Opporunity for audience feedback

Introduction and Background

Relevance

Introduction and Background

Relevance

Key Areas: Cardiovascular disease, diabetes, heart failure, sepsis

Clinical Implications

Early Detection and Prevention: Monitoring microvascular function helps identify patients at high risk, enabling early intervention and preventive measures.

Disease Progression and Treatment Monitoring: Microvascular assessment provides a window into disease activity, aiding in the evaluation of treatment effectiveness.

Goal-directed therapy: Insights into microvascular health support goal-directed therapies, optimizing treatment plans tailored to individual needs.

Introduction and Background

Problem

Current methods

Capillary refill time Subjectivity, variability, sens/spec, non-quantifiable*

Coronary angiography Invasive, cumbersome, resource intensive, organ specific

Stress Cardiac MRT Cumbersome, resource intensive, organ specific

Biomarkers Analysis time, interpretation, resource intensive

Introduction and Background

Problem

Future methods - what is needed?

Quantitative Precision and comparison

Non-invasive Risk and discomfort

Low variability and High sensitivity Consistency and precision

Rapid and ease of use Clinical convenience

Organ-agnostic Systemic dysfunction

Cost-effective Iterative usage and goal-directed

Research plan and Methodology

.

Timeline and Milestones

gantt
    dateFormat YYYY-MM
    section Mandatory courses
        Medical Research Ethics                     :active               2025-01, 2025-02
        Basic Laboratory Safety                     :active               2025-01, 2025-02
        Introduction to Doctoral Education at KI    :active               2025-01, 2025-02
        Basic Course in Medical Statistics          :active               2025-02, 2025-03
        Present your Research!                      :active               2025-08, 2025-09
        Quality Assurance of Clinical Research      :active               2025-09, 2025-10
    section Project specific courses
        Statistical Methods with R                  :active               2024-09, 2024-12
        Programing in Python                        :active               2024-08, 2024-11
        Endothelial Cell Function[...]              :active               2026-02, 2026-03
        Intermediate Medical Statistics             :active               2026-03, 2026-04
        Cellular Signalling                         :active               2026-04, 2026-05
    section Clinical studies
        Microangiopathy IN Diabetes(MIND)           :active               2024-01, 2026-01
        Capillary dysfunction in Sepsis(CapriS)     :active               2024-01, 2027-01
        SCAPIS2Spectrum - Microcirculation substudy :active               2024-06, 2029-01
    section Journal clubs
        IMA-journal clubs                           :active               2024-06, 2029-01
    section Conferences
        European Society on Microcirculation        :active, milestone    2025-05, 2025-06
        ISICEM                                      :active, milestone    2026-03, 2026-04
        European Society on Microcirculation        :active, milestone    2027-04, 2027-05
    section Significant Milestones
        Start date                                  :milestone,           2024-08, 2024-08
        Half Time Control                           :milestone,           2026-08, 2026-08
        Dissertation Defence                        :milestone, crit,     2029-05, 2029-05

Resources and Support

  • Summary: Key points discussed.

Challanges and Risk Management

  • Many challanges wow

Discussion and Feedback

  • So much feedback!